Journal
MOLECULES
Volume 17, Issue 11, Pages 13656-13661Publisher
MDPI AG
DOI: 10.3390/molecules171113656
Keywords
Clerodendranthus spicatus; Lamiaceae; phenolic compounds
Funding
- technological large platform for comprehensive research and development of new drugs in the Twelfth Five-Year [2012ZX09301-002-001-033]
- innovation system construction of Yao medicine
- technological large platform for Guanxi pharmaceutical industry [10100027-3]
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Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS.
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