Journal
MOLECULES
Volume 17, Issue 5, Pages 5882-5892Publisher
MDPI
DOI: 10.3390/molecules17055882
Keywords
click chemistry; 1,2,3-triazoles; Candida spp.; antifungal activity
Funding
- CAPES
- CNPq
- PPP/FACEPE
- PRONEX/FACEPE
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1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H-1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different Candida species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl)-1H-(1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.
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