Journal
MOLECULES
Volume 17, Issue 7, Pages 8471-8482Publisher
MDPI AG
DOI: 10.3390/molecules17078471
Keywords
Foeniculum vulgare (F. vulgare); Mycobacterium tuberculosis; multidrug resistant (MDR); 5-hydroxyfuranocoumarin
Funding
- Consejo Nacional de Ciencia y Tecnologia (CONACYT) [CB-106107]
- Programa de Apoyo a la Investigacion Cientifica y Tecnologica (PAICYT)-UANL [SA1627-07]
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Bioassay guided fractionation of an antimycobacterial extract of Foeniculum vulgare var dulce (Apiaceae) led to the isolation and characterization of 5-hydroxyfuranocoumarin. The chemical structure of this compound was elucidated by H-1 and C-13 (1D and 2D) Nuclear Magnetic Resonance (NMR) spectroscopy. In addition, the active fractions were analyzed by GC-MS and seventy eight compounds were identified; the major compounds were 1,3-benzenediol, 1-methoxycyclohexene, o-cymene, sorbic acid, 2-hydroxy-3-methyl-2-cyclopenten-1-one, estragole, limonene-10-ol and 3-methyl-2-cyclopenten-1-one. Twenty compounds identified in the active fractions were tested against one sensitive and three MDR strains of Mycobacterium tuberculosis using the Alamar Blue microassay. Compounds that showed some degree of antimycobacterial activity against all strains tested were the following: linoleic acid (MIC 100 mu g/mL), oleic acid (MIC 100 mu g/mL), 1,3-benzenediol (MIC 100-200 mu g/mL), undecanal (MIC 50-200 mu g/mL), and 2,4-undecadienal (MIC 25-50 mu g/mL), the last being the most active compound. To our knowledge, this is the first report of the presence of 5-hydroxyfuranocoumarin in F. vulgare.
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