Journal
MOLECULES
Volume 17, Issue 5, Pages 5972-5987Publisher
MDPI
DOI: 10.3390/molecules17055972
Keywords
curcumin; phospholipids; liposomes; skin penetration; antimelanoma activity
Funding
- Jiangsu Provincial Chinese Medicine Leading Talent project [LJ200913]
- Project of Research and Innovation Plans of Graduate Students in Jiangsu Province [CX10B-373Z]
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This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of curcumin-loaded liposomes: C-SPC-L (curcumin-loaded SPC liposomes), C-EPC-L (curcumin-loaded EPC liposomes), and C-HSPC-L (curcumin-loaded HSPC liposomes). The physical properties of different lipsomes were investigated as follows: photon correlation spectroscopy revealed that the average particle sizes of the three types of curcumin-loaded liposomes were 82.37 +/- 2.19 nm (C-SPC-L), 83.13 +/- 4.89 nm (C-EPC-L), and 92.42 +/- 4.56 nm (C-HSPC-L), respectively. The encapsulation efficiency values were found to be 82.32 +/- 3.91%, 81.59 +/- 2.38%, and 80.77 +/- 4.12%, respectively. An in vitro skin penetration study indicated that C-SPC-L most significantly promoted drug permeation and deposition followed by C-EPC-L, C-HSPC-L, and curcumin solution. Moreover, C-SPC-L displayed the greatest ability of all loaded liposomes to inhibit the growth of B16BL6 melanoma cells. Therefore, the C-SPC-L were chosen for further pharmacodynamic evaluation. A significant effect on antimelanoma activity was observed with C-SPC-L, as compared to treatment with curcumin solution in vivo. These results suggest that C-SPC-L would be a promising transdermal carrier for curcumin in cancer treatment.
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