Journal
MOLECULES
Volume 17, Issue 1, Pages 664-673Publisher
MDPI
DOI: 10.3390/molecules17010664
Keywords
Monascus purpureus NTU 568; azaphilone; monapurpyridine A; cytotoxicity; apoptosis
Funding
- National Science Council (NSC)
- National Research Institute of Chinese Medicine (NRICM), Taiwan, China
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A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568. The structure of MPA was elucidated by nuclear magnetic resonance (H-1-NMR, C-13-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Biological evaluation revealed that MPA could induce cell death in human breast adenocarcinoma cells MCF-7, and it has no significant toxicity to normal mammary epithelial cells M10. The MTT assay and flow cytometric analysis were employed to investigate cell viability and cell cycle influenced by MPA. Moreover, we used Western blot and caspase activity assay to demonstrate the activation of caspase-3, -8 and -9 resulted from MPA. All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer.
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