Journal
MOLECULES
Volume 17, Issue 5, Pages 5095-5107Publisher
MDPI
DOI: 10.3390/molecules17055095
Keywords
1,3,4-oxadiazole; N-acylhydrazone; Staphylococcus aureus; drug-likeness
Funding
- CNPq
- CAPES
- PRONEX/FAPESQ-PB
Ask authors/readers for more resources
Five new 1-(2-(5-nitrofuran-2-yl)-5-(aryl)-1,3,4-oxadiazol-3-(2H)-yl) ethanone compounds 5a-e were synthesized by cyclization of N-acylhydrazones 4a-e with acetic anhydride under reflux conditions. Their structures were fully characterized by IR, H-1-NMR, and C-13-NMR. Furthermore, evaluations of the antibacterial activity of the 1,3,4-oxadiazoles 5a-e and N-acylhydrazones 4a-e showed strong activity against several strains of Staphylococcus aureus, with MICs between 4 mu g/mL to 32 mu g/mL. In silico studies of the parameters of Lipinski's Rule of Five, as well as the topological polar surface area (TPSA), absorption percentage (% ABS), drug likeness and drug score indicate that these compounds, especially 4a and 5d, have potential to be new drug candidates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available