Journal
MOLECULES
Volume 17, Issue 1, Pages 1074-1102Publisher
MDPI
DOI: 10.3390/molecules17011074
Keywords
multicomponent reaction; MCR; MFCR; I-MCR; isocyanide; heterocycle; diversity oriented synthesis; solvent-less synthesis; alternative energy; microwave
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A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.
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