Journal
MOLECULES
Volume 17, Issue 4, Pages 4028-4036Publisher
MDPI
DOI: 10.3390/molecules17044028
Keywords
naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity
Funding
- University Malaya, Malaysia [UMRG045/11BIO]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- CNRS, France
- Herbarium Group, University of Malaya
- Grants-in-Aid for Scientific Research [22510239] Funding Source: KAKEN
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A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete C-13-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 x 10(-5) M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 x 10(-5) M) on an isolated rat aorta.
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