Journal
MOLECULES
Volume 17, Issue 4, Pages 4508-4521Publisher
MDPI AG
DOI: 10.3390/molecules17044508
Keywords
indazoles; pyrrole; thiophene; Suzuki cross-coupling; heterobiaryl compounds
Funding
- Sapienza University of Rome
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The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K2CO3, dimethoxyethane and Pd(dppf)Cl-2 as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
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