Journal
MOLECULES
Volume 17, Issue 12, Pages 13856-13863Publisher
MDPI
DOI: 10.3390/molecules171213856
Keywords
pyrano[3,2-c]quinolin-2,5(6H)-dione; multi-component reaction; L-proline
Funding
- Natural Science Foundation of Higher Education Institutions of Jiangsu Province [09KJB150012]
- Key Laboratory of Cancer Biotherapy of Xuzhou Medical College [C0901]
- Key Laboratory of Organic Synthesis of Jiangsu Province [KJS1010]
- Special Presidential Foundation of Xuzhou Medical College [2010KJZ20]
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A series of 4-aryl-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-2,5(6H)-diones were synthesized via the three-component reactions of aromatic aldehydes, 4-hydroxy-1-methylquinolin-2(1H)-one, and Meldrum's acid catalyzed by L-proline. The structures of the products were identified by spectroscopic analysis. A mechanism for this three-component reaction catalyzed by L-proline was proposed.
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