Journal
MOLECULES
Volume 17, Issue 12, Pages 14058-14066Publisher
MDPI AG
DOI: 10.3390/molecules171214058
Keywords
Sinularia; norcembranoidal diterpene; cytotoxicity
Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium [10120022]
- Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University [00C-0302-05]
- Department of Health Clinical Trial and Research Center of Excellence [DOH101-TD-C-111-004]
- National Science Council, Taiwan [NSC 101-2325-B-291-001, 100-2325-B-291-001, 101-2320-B-291-001-MY3, 98-2320-B-291-001-MY3]
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Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.
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