Journal
MOLECULES
Volume 16, Issue 4, Pages 3146-3151Publisher
MDPI
DOI: 10.3390/molecules16043146
Keywords
aromatase; Atractylodes macrocephala; atractylenolide
Funding
- Foundation of Zhejiang Administration of Traditional Chinese Medicine [2009CA045]
- Foundation of Zhejiang Educational Committee [Y200805085]
- Foundation of Zhejiang Medical College [2008XZA01]
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Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 +/- 0.70%, 90.93 +/- 1.41% and 86.31 +/- 8.46%, respectively, at a concentration of 10 mu M. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.
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