Journal
MOLECULES
Volume 16, Issue 8, Pages 6732-6740Publisher
MDPI
DOI: 10.3390/molecules16086732
Keywords
Alzheimer's disease; berberine; multipotent agent
Funding
- National Natural Science Foundation of China [30800184]
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With the accelerated aging of human society Alzheimer's disease (AD) has become one of the most threatening diseases in the elderly. However, there is no efficient therapeutic agent to combat AD. Berberine is a natural isoquinoline alkaloid that possesses a wide range of pharmacological effects. In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-beta peptide level-reducing and cholesterol-lowering activities, which suggest that berberine may act as a promising multipotent agent to combat AD.
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