Journal
MOLECULES
Volume 16, Issue 11, Pages 9207-9217Publisher
MDPI
DOI: 10.3390/molecules16119207
Keywords
Allium schoenoprasum; Tragopogon pratensis; Rumex acetosa; proliferation; phenolic compounds; HaCaT
Funding
- Operational Program Research and Development for Innovations
- European Regional Development Fund (ERDF)
- national budget of the Czech Republic, within the framework of the Centre of Polymer Systems project [CZ.1.05/2.1.00/03.0111]
- Ministry of Education, Youth and Sports of the Czech Republic [MSM 7088352101]
- TBU at Zlin [IGA/20/FT/11/D]
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Experimental studies have shown that phenolic compounds have antiproliferative and tumour arresting effects. The aim of this original study was to investigate the content of phenolic compounds (PhC) in flowers of Allium schoenoprasum (chive), Tragopogon pratensis (meadow salsify) and Rumex acetosa (common sorrel) and their effect on proliferation of HaCaT cells. Antiproliferative effects were evaluated in vitro using the following concentrations of phenolic compounds in cultivation medium: 100, 75, 50 and 25 mu g/mL. Phenolic composition was also determined by HPLC. The results indicate that even low concentrations of these flowers' phenolic compounds inhibited cell proliferation significantly and the possible use of the studied herb's flowers as sources of active phenolic compounds for human nutrition.
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