Journal
MOLECULES
Volume 16, Issue 3, Pages 2084-2096Publisher
MDPI
DOI: 10.3390/molecules16032084
Keywords
Elsholtzia rugulosa; luteolin; Alzheimer's disease; amyloid-beta peptide; copper
Funding
- National Natural Science Foundation of China [81073120]
- Major Scientific and Technological Special Project for Significant New Drugs Creation [2009ZX09302-003, 2009ZX09102-034, 2009ZX09102-123]
- National Young Research Fund Project [2011CHX01]
- International S&T Cooperation Program of China [2009DFA32010]
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Luteolin, a 3', 4', 5,7-tetrahydroxyflavone, is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species. In the present study, the effects of luteolin obtained from the medicinal plant Elsholtzia rugulosa and the related mechanisms were examined in an Alzheimer's disease (AD) cell model. In this model, copper was used to exacerbate the neurotoxicity in beta-amyloid precursor protein Swedish mutation stably overexpressed SH-SY5Y cells (named APPsw cells for short). Based on this model, we demonstrated that luteolin increased cell viability, reduced intracellular ROS generation, enhanced the activity of SOD and reversed mitochondrial membrane potential dissipation. Inhibition of caspase-related apoptosis was consistently involved in the neuroprotection afforded by luteolin. Furthermore, it down-regulated the expression of A beta PP and lowered the secretion of A beta(1-42). These results indicated that luteolin from the Elsholtzia rugulosa exerted neroprotective effects through mechanisms that decrease A beta PP expression, lower A beta secretion, regulate the redox imbalance, preserve mitochondrial function, and depress the caspase family-related apoptosis.
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