Journal
MOLECULES
Volume 16, Issue 7, Pages 6010-6022Publisher
MDPI AG
DOI: 10.3390/molecules16076010
Keywords
Morus alba var. multicaulis Perro; arylbenzofuran; prenyl-flavonoid; adipocyte; macrophage
Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [20590016]
- Japan Science Society
- Grants-in-Aid for Scientific Research [20590016] Funding Source: KAKEN
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A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), beta-sitosterol (20), oxyresveratrol 2-O-beta-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-beta-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-beta-D-apiofuranosyl-(1 -> 6)-O-beta-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae). Their structures were determined by spectroscopic methods. The prenyl-flavonoids 11-14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes. The arylbenzofurans 1-10 and prenyl-flavonoids 11-16 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.
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