Journal
MOLECULES
Volume 16, Issue 6, Pages 4642-4651Publisher
MDPI AG
DOI: 10.3390/molecules16064642
Keywords
Sanguisorba tenuifolia var. Alba; triterpenoids; alpha-glucosidase inhibitory activity; diabetes mellitus
Funding
- Major Sate Basic Research Development Program of China (973 Program) [2006CB504708]
- National Natural Science Foundation of China [30371736, 30672633]
- Special Fund Project of National Excellent Doctoral Dissertation of China [200980]
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The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3 beta,19 alpha-dihydroxyolean-12-en-28-oic acid beta-D-gluco-pyranosyl ester (1) and 2 alpha,19 alpha-dihydroxy-3-oxo-12-ursen-28-oic acid beta-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against alpha-glucosidase with IC(50) values in the 0.62-3.62 mM range.
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