Journal
MOLECULES
Volume 16, Issue 12, Pages 9912-9924Publisher
MDPI
DOI: 10.3390/molecules16129912
Keywords
oxidative stress; diabetes mellitus; salidroside; hypoglycemic; mice
Funding
- Natural Sciences Foundation of Jilin Province [20090905]
- Natural Science Foundation for Young Scientists of Jilin Agricultural Science and Technology College [2010124]
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It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.
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