Journal
MOLECULES
Volume 16, Issue 6, Pages 4912-4922Publisher
MDPI AG
DOI: 10.3390/molecules16064912
Keywords
terpy-DNA; AFM; TEM; DNA nanotubes
Funding
- ATDbio (Southampton)
- EPSRC [EP/E045693/1, EP/F34296/1]
- EPSRC [EP/E045693/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E045693/1] Funding Source: researchfish
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We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
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