Journal
MOLECULES
Volume 16, Issue 7, Pages 5629-5646Publisher
MDPI
DOI: 10.3390/molecules16075629
Keywords
marine anticancer compounds; natural analogues; synthetic derivatives; cancer
Funding
- Recherche Cancer et Sang
- Recherches Scientifiques Luxembourg association
- Een Haerz fir kriibskrank Kanner association
- Action Lions Vaincre le Cancer association
- Televie Luxembourg
- Fonds National de la Recherche Luxembourg
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Although considerable progress in oncology therapeutics has been achieved in the last century, cancer remains one of major death causes in the World and for this reason, the development of novel cancer drugs remains a pressing need. Natural marine compounds represent an interesting source of novel leads with potent chemotherapeutic or chemo-preventive activities. In the last decades, structure-activity-relationship studies have led to the development of naturally-derived or semi-synthetic analogues with improved bioactivity, a simplified synthetic target or less toxicity. We aim here to review a selection of natural compounds with reported anticancer activity isolated of marine sources and their associated analogues published in 2010.
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