Journal
MOLECULES
Volume 15, Issue 10, Pages 7075-7082Publisher
MDPI
DOI: 10.3390/molecules15107075
Keywords
Litsea cubeba; Lauraceae; (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide; litseacubebic acid; essential oil; fungicidal activity
Funding
- National High-tech Research & Development Program of China [2006AA10A209]
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A new C-9 monoterpenoid acid (litseacubebic acid, 1) and a known monoterpene lactone (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide (2), along with three known compounds - vanillic acid (3), trans-3,4,5-trimethoxylcinnamyl alcohol (4), and oxonantenine (5) - were isolated with bioassay-guided purification from the fruit extract of Litsea cubeba collected in Tibet. The structure of 1 was elucidated by MS, H-1-NMR, C-13-NMR, COSY, HSQC, HMBC, NOE spectral data as 2,6-dimethyl-6-hydroxy-2E,4E-hepta-2,4-diene acid. Additionally 33 compounds were identified from the essential oil of L. cubeba. The preliminary bioassay results showed that 1 and 2 have good fungicidal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris, Pseudocer-cospora musae and Colletotrichum gloeosporioides at the concentration of 588 and 272 mu M, and the essential oil has good fungicidal activities against T. cucumeris and S. sclerotiorum, with IC50 values of 115.58 and 151.25 mu g/mL, repectively.
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