Journal
MOLECULES
Volume 15, Issue 3, Pages 1531-1553Publisher
MDPI
DOI: 10.3390/molecules15031531
Keywords
vitamin K-2; menaquinone; electron transport system; menaquinone biosynthesis; MenA; menaquinone biosynthesis inhibitor; electron transport system inhibitor; antibacterial agent; multidrug-resistant bacteria
Funding
- Global Alliance for TB Drug Development (TB Alliance)
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Aerobic and anaerobic respiratory systems allow cells to transport the electrons to terminal electron acceptors. The quinone (ubiquinone or menaquinone) pool is central to the electron transport chain. In the majority of Gram-positive bacteria, vitamin K-2 (menaquinone) is the sole quinone in the electron transport chain, and thus, the bacterial enzymes catalyzing the synthesis of menaquinone are potential targets for the development of novel antibacterial drugs. This manuscript reviews the role of vitamin K in bacteria and humans, and especially emphasizes on recent aspects of menaquinones in bacterial electron transport chain and on discoveries of inhibitor molecules targeting bacterial electron transport systems for new antibacterial agents.
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