Journal
MOLECULES
Volume 15, Issue 4, Pages 2203-2210Publisher
MDPI
DOI: 10.3390/molecules15042203
Keywords
gold; N-heterocyclic carbene; metallopharmaceutical agent; antimicrobial; benzimidazol-2-ylidene
Funding
- Technological and Scientific Research Council of Turkey TUBITAK [TBAG (108T411)]
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Gold(I) N-heterocyclic carbene (NHC) complexes were obtained in good yields from the corresponding silver complexes by treatment with [AuCl(PPh3)] following the commonly used silver carbene transfer route. The silver complexes were synthesized from the benzimidazolium halide salts by the in situ reactions with Ag2O in dichloromethane as a solvent at room temperature. All gold complexes have been characterized by H-1-NMR, C-13-NMR and IR spectroscopy and elemental analysis. Au-NHC complexes were evaluated for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria and fungal species.
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