Journal
MOLECULES
Volume 15, Issue 10, Pages 7035-7074Publisher
MDPI
DOI: 10.3390/molecules15107035
Keywords
dietary polyphenolic antioxidants; resveratrol; curcumin and derivatives; leukemia
Funding
- Fonds National de la Recherche Luxembourg
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg asbl
- Een Haerz fir Kriibskrank Kanner association
- Action Lions Vaincre le Cancer Luxembourg
- Televie Luxembourg
- Foundation for Scientific Cooperation
- University of Saarland
- Ministry of Economics and Science of Saarland
- Deutsche Forschungsgemeinschaft (DFG) [JA1741/2-1, HE3553/2-1]
- European Union [215009]
- Fonds National de la Recherche - Luxembourg
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Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic agents, the mortality of hematological malignancies is still high due to therapy relapse, which is associated with bad prognosis. Dietary polyphenolic compounds are of growing interest as an alternative approach, especially in cancer treatment, as they have been proven to be safe and display strong antioxidant properties. Here, we provide evidence that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for future treatment of leukemia. Both polyphenols are currently being tested in clinical trials. We describe the underlying mechanisms, but also focus on possible limitations and how they might be overcome in future clinical use - either by chemically synthesized derivatives or special formulations that improve bioavailability and pharmacokinetics.
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