Journal
MOLECULES
Volume 15, Issue 9, Pages 6019-6034Publisher
MDPI
DOI: 10.3390/molecules15096019
Keywords
type III secretion; Suzuki coupling; Grignard addition
Funding
- Swedish Research Council
- Carl Trygger Foundation
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A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
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