Journal
MOLECULES
Volume 15, Issue 6, Pages 4423-4438Publisher
MDPI
DOI: 10.3390/molecules15064423
Keywords
scaffold hopping; Reformatsky reaction; salicylidene acylhydrazide; type III secretion
Funding
- Swedish National Research Council
- Swedish Governmental Agency for Innovation Systems (VINNOVA)
- Carl Trygger foundation
- Creative Antibiotics
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Salicylidene acylhydrazides are inhibitors of type III secretion in several Gram-negative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-aminopyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a library of 2-( 2- aminopyrimidine)-2,2- difluoro-ethanols is described in this paper.
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