Journal
MOLECULES
Volume 15, Issue 4, Pages 2782-2790Publisher
MDPI
DOI: 10.3390/molecules15042782
Keywords
p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum
Funding
- National High Technology Development Project (863 project) [2008AA09Z405]
- National Science Foundation of China [30901845]
- German Federal Ministry for Education and Research and Technology [0312849A, CHN 02/322]
- SRF for ROCS, SEM
- New Teacher Program of Higher Education of China [20090001120047]
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Four new p-aminoacetophenonic acids, named (2E)-11-(4'-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4'-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid (2), (2E)-11-(4'-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4'-aminophenyl)-3,7-O-cyclo-2,4,6trimethyl-9-oxo-nonoic acid (4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1-4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1-4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn't active against VSVG/HIV-luc pseudotyping virus.
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