Journal
MOLECULES
Volume 15, Issue 11, Pages 8327-8348Publisher
MDPI AG
DOI: 10.3390/molecules15118327
Keywords
multifunctional catalyst; thiourea; Ru-catalyzed Huisgen cycloaddition; asymmetric induction; hydrogen bonding
Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Takeda Science Foundation
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The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1,5-disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an alpha,beta-unsaturated imide.
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