Journal
MOLECULES
Volume 14, Issue 5, Pages 1725-1746Publisher
MDPI
DOI: 10.3390/molecules14051725
Keywords
DNA; RNA; photointercalators; fluorescence; rational design; therapy; cancer
Funding
- FAPDF
- CAPES
- CNPq
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In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.
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