Journal
MOLECULES
Volume 14, Issue 5, Pages 1789-1795Publisher
MDPI
DOI: 10.3390/molecules14051789
Keywords
Agave sisalana Perrine ex Engelm.; homoisoflavonoid; PBMC; IL-2; IFN-gamma
Funding
- National Science Council of the Republic of China
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Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalana Perrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by H-3-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 mu M, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.
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