Journal
MOLECULES
Volume 14, Issue 1, Pages 528-539Publisher
MDPI
DOI: 10.3390/molecules14010528
Keywords
Click chemistry; Huisgen's cycloaddition; Copper (I) catalysis; Triazoles; Supported catalyst; Solvent-free
Funding
- Ile-de-France [CNRS 8151, INSERM U640]
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A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst (R) A21 center dot CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a flash synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
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