4.6 Article

Synthesis of γ-Nitro Aliphatic Methyl Esters Via Michael Additions Promoted by Microwave Irradiation

Journal

MOLECULES
Volume 14, Issue 4, Pages 1595-1604

Publisher

MDPI
DOI: 10.3390/molecules14041595

Keywords

Microwave irradiation; alpha, beta-Unsaturated; Michael additions; gamma-Nitro aliphatic methyl esters; Catalysis

Funding

  1. CONACYT [48356-Q]
  2. CONACyT

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A simple and efficient protocol has been developed for the direct synthesis of gamma-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

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