Journal
MOLECULES
Volume 14, Issue 10, Pages 3952-3963Publisher
MDPI
DOI: 10.3390/molecules14103952
Keywords
indolyl-nitroalkane; N-bromosuccinimide; nitroalkenes; Friedel-Crafts alkylation
Funding
- National Science Council of the Republic of China
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An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different beta-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.
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