Journal
MOLECULES
Volume 13, Issue 6, Pages 1406-1426Publisher
MOLECULAR DIVERSITY PRESERVATION INT
DOI: 10.3390/molecules13061406
Keywords
natural products; pre-fractionated libraries; high-throughput screening; drug discovery; pharmaceutical industry
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From the beginning of the antibiotic era in the 1940s to the present, Wyeth has sustained an active research program in the area of natural products discovery. This program has continually evolved through the years in order to best align with the current drug discovery paradigm in the pharmaceutical industry. The introduction of high-throughput screening and the miniaturization of assays have created a need to optimize natural product samples to better suit these new technologies. Furthermore, natural product programs are faced with an ever shortening time period from hit detection to lead characterization. To address these issues, Wyeth has created a pre-fractionated natural products library using reversed-phase HPLC to complement their existing library of crude extracts. The details of the pre-fractionated library and a cost-benefit analysis will be presented in this review.
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