Journal
MOLECULES
Volume 13, Issue 1, Pages 69-77Publisher
MOLECULAR DIVERSITY PRESERVATION INT
DOI: 10.3390/molecules13010069
Keywords
quinoxaline; N-oxides; malaria; antiplasmodial; P. falciparum
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The aim of this study was to identify new compounds active against Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline2- carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed an IC50 < 1 mu M against the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 mu M) and good selectivity (SI= 10.35), thereby becoming a new lead-compound.
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