Journal
MOLECULES
Volume 13, Issue 1, Pages 96-106Publisher
MDPI
DOI: 10.3390/molecules13010096
Keywords
aliphatic polyesters; ring-opening polymerization; macromolecular prodrugs; prodrugs of norfloxacin
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Two-, three- and four-arm, star-shaped poly(epsilon-caprolactone) and poly(D, L-lactide) homopolymers, and copolymers of epsilon-caprolactone with D, L-lactide were synthesized via ring-opening polymerization of cyclic esters in the presence of glycerol, penthaerythritol and poly(ethylene glycol) as initiators and stannous octoate as a catalyst. Thus obtained oligomers were successfully used in the synthesis of novel macromolecular prodrugs of norfloxacin. The structures of the polymers and prodrugs were elucidated by means of MALDI-TOF MS, NMR and IR studies.
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