Journal
MOLECULAR THERAPY
Volume 22, Issue 6, Pages 1075-1083Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mt.2014.30
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Funding
- National Institutes of Health [EB014277]
- China Scholarship Council [201208320185]
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Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.
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