Journal
MOLECULAR SYSTEMS BIOLOGY
Volume 9, Issue -, Pages -Publisher
WILEY
DOI: 10.1038/msb.2013.15
Keywords
aging; apoptosis; influenza; systems immunology; vaccinology
Categories
Funding
- Ellison Medical Foundation [AG-SS-1788]
- Howard Hughes Medical Institute
- National Institutes of Health [U19 AI057229, U19 AI090019, M01 RR00070, HHSN288201000034C, U19-AI050864]
- Donald E. and Delia B. Baxter Foundation
- Euro Commission, European Union Seventh Framework Program [261, 261382]
- Stanford Center on Longevity
Ask authors/readers for more resources
Despite the importance of the immune system in many diseases, there are currently no objective benchmarks of immunological health. In an effort to identifying such markers, we used influenza vaccination in 30 young (20-30 years) and 59 older subjects (60 to >89 years) as models for strong and weak immune responses, respectively, and assayed their serological responses to influenza strains as well as a wide variety of other parameters, including gene expression, antibodies to hemagglutinin peptides, serum cytokines, cell subset phenotypes and in vitro cytokine stimulation. Using machine learning, we identified nine variables that predict the antibody response with 84% accuracy. Two of these variables are involved in apoptosis, which positively associated with the response to vaccination and was confirmed to be a contributor to vaccine responsiveness in mice. The identification of these biomarkers provides new insights into what immune features may be most important for immune health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available