Journal
MOLECULAR SYSTEMS BIOLOGY
Volume 9, Issue -, Pages -Publisher
WILEY
DOI: 10.1038/msb.2013.50
Keywords
-
Categories
Funding
- NIH [R01GM44619]
- Israeli Centers for Research Excellence (I-CORE)
- Israel Cancer Association (ICA), Israel Cancer Research Fund (ICRF)
- USIsrael Binational Science Fund (BSF)
- Fritz Thyssen Stiftung, Marie Curie Career Integration Grants (CIG)
- German Cancer Research Center (DKFZ)
Ask authors/readers for more resources
Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we determined that sets of genes associated with particular diseases have similar phylogenetic profiles. By focusing on those human phylogenetic gene clusters that significantly overlap some of the thousands of human gene sets defined by their coexpression or annotation to pathways or other molecular attributes, we reveal the evolutionary map that connects molecular pathways and human diseases. The other genes in the phylogenetic clusters enriched for particular known disease genes or molecular pathways identify candidate genes for roles in those same disorders and pathways. Focusing on proteins coevolved with the microphthalmia-associated transcription factor (MITF), we identified the Notch pathway suppressor of hairless (RBP-Jk/SuH) transcription factor, and showed that RBP-Jk functions as an MITF cofactor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available