Journal
MOLECULAR SYSTEMS BIOLOGY
Volume 6, Issue -, Pages -Publisher
WILEY
DOI: 10.1038/msb.2010.31
Keywords
B cell; germinal centers; interactome; master regulator
Categories
Funding
- National Cancer Institute [R01CA109755]
- National Institute of Allergy and Infectious Diseases [R01AI066116]
- In Silico Research Centre of Excellence [NCI-caBIG 29XS192]
- National Centers for Biomedical Computing NIH Roadmap Initiative [U54CA121852]
- National Institute of General Medical Sciences [5R01GM085659-02]
- National Institute on Drug Abuse [5R01DA013821-06]
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Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre-replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues. Molecular Systems Biology 377; published online 8 June 2010; doi:10.1038/msb.2010.31
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