Journal
MOLECULAR SYSTEMS BIOLOGY
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/msb.2010.73
Keywords
comprehensive map; large-scale network; yeast cell cycle
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Funding
- Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science, and Technology
- New Energy Development Organization
- Okinawa Institute of Science and Technology
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With the accumulation of data on complex molecular machineries coordinating cell-cycle dynamics, coupled with its central function in disease patho-physiologies, it is becoming increasingly important to collate the disparate knowledge sources into a comprehensive molecular network amenable to systems-level analyses. In this work, we present a comprehensive map of the budding yeast cell-cycle, curating reactions from B600 original papers. Toward leveraging the map as a framework to explore the underlying network architecture, we abstract the molecular components into three planes-signaling, cell-cycle core and structural planes. The planar view together with topological analyses facilitates network-centric identification of functions and control mechanisms. Further, we perform a comparative motif analysis to identify around 194 motifs including feed-forward, mutual inhibitory and feedback mechanisms contributing to cell-cycle robustness. We envisage the open access, comprehensive cell-cycle map to open roads toward community-based deeper understanding of cell-cycle dynamics. Molecular Systems Biology 6: 415; published online 21 September 2010; doi:10.1038/msb.2010.73
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