Journal
MOLECULAR SIMULATION
Volume 36, Issue 1, Pages 53-57Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927020903096098
Keywords
p21-activated kinase 4; pharmacophore model; molecular docking; kinase inhibitor; drug discovery
Funding
- National Natural Science Foundation of China [90813038]
- National High Technology Research and Development Program of China [2007AA02Z305]
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p21-activated kinase 4 (PAK4) is a serine-threonine protein kinase which plays an important role in a wide variety of human diseases including cancer. The inhibition of this kinase is of great interest for the treatment of cancer. In the present study, we report three pharmacophore models of PAK4 based on a small set of PAK4 inhibitors, a crystal structure of PAK4 and a docked complex between PAK4 and a potent inhibitor. These results might provide useful and reliable tools in identifying structurally diverse compounds with desired biological activity.
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