Journal
MOLECULAR PSYCHIATRY
Volume 19, Issue 11, Pages 1156-1162Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2014.111
Keywords
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Funding
- National Institute on Mental Health [R21MH102834]
- Department of Veterans Affairs [1I01BX002150-01]
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Post-traumatic stress disorder (PTSD) is associated with elevated risk for a variety of age-related diseases and neurodegeneration. In this paper, we review evidence relevant to the hypothesis that chronic PTSD constitutes a form of persistent life stress that potentiates oxidative stress (OXS) and accelerates cellular aging. We provide an overview of empirical studies that have examined the effects of psychological stress on OXS, discuss the stress-perpetuating characteristics of PTSD, and then identify mechanisms by which PTSD might promote OXS and accelerated aging. We review studies on OXS-related genes and the role that they may have in moderating the effects of PTSD on neural integrity and conclude with a discussion of directions for future research on antioxidant treatments and biomarkers of accelerated aging in PTSD.
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