Journal
MOLECULAR PSYCHIATRY
Volume 17, Issue 1, Pages 99-107Publisher
SPRINGERNATURE
DOI: 10.1038/mp.2011.35
Keywords
PSD-95; fyn; src
Funding
- NIH-NIMH [R01MH071316]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- NIH [MH078833]
- Ruth L Kirschstein National Research Service [1F31AG031621-01A2, 1F31MH085362]
- Christopher Reeve Foundation
Ask authors/readers for more resources
Neuregulin 1 (NRG1) is a secreted trophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase. Both NRG1 and erbB4 have been repeatedly associated with schizophrenia, but their downstream targets are not well characterized. ErbB4 is highly abundant in interneurons, and NRG1-mediated erbB4 activation has been shown to modulate interneuron function, but the role for NRG1-erbB4 signaling in regulating interneuron dendritic growth is not well understood. Here we show that NRG1/erbB4 promote the growth of dendrites in mature interneurons through kalirin, a major dendritic Rac1-GEF. Recent studies have shown associations of the KALRN gene with schizophrenia. Our data point to an essential role of phosphorylation in kalirin-7's C terminus as the critical site for these effects. As reduced interneuron dendrite length occurs in schizophrenia, understanding how NRG1-erbB4 signaling modulates interneuron dendritic morphogenesis might shed light on disease-related alterations in cortical circuits. Molecular Psychiatry (2012) 17, 99-107; doi:10.1038/mp.2011.35; published online 12 April 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available