Journal
MOLECULAR PSYCHIATRY
Volume 15, Issue 8, Pages 844-849Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2009.21
Keywords
bipolar disorder; depression; association; psychosis
Funding
- Austrian Science Funds [J2647]
- INTAS Postdoctoral Fellowship [04-83-3802]
- Russian Science Support Foundation
- Medical Research Council (MRC) UK
- GlaxoSmithKline, Research and Development
- MRC [G0701003, G0600204] Funding Source: UKRI
- Medical Research Council [G0600204, G9817803B, G0701003] Funding Source: researchfish
- Austrian Science Fund (FWF) [J2647] Funding Source: Austrian Science Fund (FWF)
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The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene. Molecular Psychiatry (2010) 15, 844-849; doi: 10.1038/mp.2009.21; published online 3 March 2009
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