Journal
MOLECULAR PSYCHIATRY
Volume 15, Issue 1, Pages 18-22Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2009.123
Keywords
gene-environment interactions; serotonin transporter; depression; stressful life events; adversity; adolescence
Funding
- Medical Research Council [G9817803B] Funding Source: researchfish
Ask authors/readers for more resources
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression. Molecular Psychiatry (2010) 15, 18-22; doi: 10.1038/mp.2009.123
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available