Journal
MOLECULAR PLANT-MICROBE INTERACTIONS
Volume 25, Issue 10, Pages 1350-1360Publisher
AMER PHYTOPATHOLOGICAL SOC
DOI: 10.1094/MPMI-02-12-0028-R
Keywords
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Funding
- National Science Foundation [05-512]
- United States Department of Agriculture
- JGI Community Sequencing Program
- Office of Science of the United States Department of Energy [DE-AC02-05CH11231]
- NIH [RR016480]
- Marie Curie Fellowship [255104]
- BBSRC
- Royal Society of Edinburgh
- Gatsby Charitable Foundation
- LOEWE Initiative of the state of Hesse
- UTIA AgResearch program
- Biotechnology and Biological Sciences Research Council [BB/I00386X/1] Funding Source: researchfish
- BBSRC [BB/I00386X/1] Funding Source: UKRI
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The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P. capsici has an explosive epidemiology, rapidly producing massive numbers of asexual spores on infected hosts. In addition, P. capsici can remain dormant for years as sexually recombined oospores, making it difficult to produce crops at infested sites, and allowing outcrossing populations to maintain significant genetic variation. Genome sequencing, development of a high-density genetic map, and integrative genomic or genetic characterization of P. capsici field isolates and intercross progeny revealed significant mitotic loss of heterozygosity (LOH) in diverse isolates. LOH was detected in clonally propagated field isolates and sexual progeny, cumulatively affecting >30% of the genome. LOH altered genotypes for more than 11,000 single-nucleotide variant sites and showed a strong association with changes in mating type and pathogenicity. Overall, it appears that LOH may provide a rapid mechanism for fixing alleles and may be an important component of adaptability for P. capsici.
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