Journal
MOLECULAR PLANT-MICROBE INTERACTIONS
Volume 24, Issue 8, Pages 918-931Publisher
AMER PHYTOPATHOLOGICAL SOC
DOI: 10.1094/MPMI-03-11-0050
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Funding
- National Science Foundation [IOB-0343327]
- National Science and Engineering Council (Canada)
- Fonds Quebecois de la Recherche sur la Nature et les Technologies
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0744652] Funding Source: National Science Foundation
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Plant genomes encode large numbers of nucleotide-binding, leucine-rich repeat (NB-LRR) proteins, many of which are active in pathogen detection and defense response induction. NB-LRR proteins fall into two broad classes: those with a Toll and interleukin-1 receptor (T1R) domain at their N-terminus and those with a coiled-coil (CC) domain at the N-terminus. Within CC-NB-LRR-encoding genes, one basal clade is distinguished by having CC domains resembling the Arabidopsis thaliana RPW8 protein, which we refer to as CCR domains. Here, we show that CCR-NB-LRR-encoding genes are present in the genomes of all higher plants surveyed, and that they comprise two distinct subgroups: one typified by the Nicotiana benthamiana N-required gene 1 (NRG 1) protein and the other typified by the Arabidopsis activated disease resistance gene I (ADR1) protein. We further report that, in contrast to CC-NB-LRR proteins, the CCR domains of both NRG land ADR1-like proteins are sufficient for the induction of defense responses, and that this activity appears to be SGT1-independent. Additionally, we report the apparent absence of both NRG1 homologs and TIR-NB-LRR-encoding genes from the dicot Aquilegia coerulea and the dicotyledonous order Lamiales as well as from monocotyledonous species. This strong correlation in occurrence is suggestive of a functional relationship between these two classes of NB-LRR proteins.
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