Journal
MOLECULAR PLANT
Volume 7, Issue 9, Pages 1406-1414Publisher
OXFORD UNIV PRESS
DOI: 10.1093/mp/ssu075
Keywords
Pol IV; Pol V; siRNA; DNA methylation; RdDM; transcriptional gene silencing
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Funding
- National Basic Research Program of China (973 Program) [2012CB910900]
- 973 Program, Chinese Ministry of Science and Technology [2011CB812600]
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RNA-directed DNA methylation (RdDM) is responsible for transcriptional silencing of endogenous transposable elements and introduced transgenes. This process requires non-coding RNAs produced by DNA-dependent RNA polymerases IV and V (Pol IV and Pol V). Pol IV-produced non-coding RNAs are precursors of 24-nt small interfering RNAs, whereas Pol V-produced ncRNAs directly act as scaffold RNAs. In this review, we summarize recent advances in the understanding of RdDM. In particular, we focus on the mechanisms underlying the recruitment of Pol IV and Pol V to chromatin and the targeting of RdDM.
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