Journal
MOLECULAR PHARMACEUTICS
Volume 11, Issue 11, Pages 3798-3809Publisher
AMER CHEMICAL SOC
DOI: 10.1021/mp500321h
Keywords
positron emission tomography/computed tomography (PET/CT); positron emission tomography/magnetic resonance imaging (PET/MRI); time-of-flight (TOF); silicon photomultiplier (SiPM); attenuation correction; oncology; neurologic disease; cardiology
Funding
- National Basic Research Program of China (973 Program) [2011CB707700]
- National Natural Science Foundation of China [81227901, 61231004, 61302024, 81371594, 81230033]
- National Key Technology RD Program [2012BAI23B01, 2012BAI23B06]
- Chinese Academy of Sciences Visiting Professorship for Senior International Scientists [2013T1G0013]
- Fellowship for Young International Scientists of the Chinese Academy of Sciences [2013Y1GB000S, 2013Y1GA0004]
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Multimodality imaging of positron emission tomography/computed tomography (PET/CT) provides both metabolic information and the anatomic structure, which is significantly superior to either PET or CT alone and has greatly improved its clinical applications. Because of the higher soft-tissue contrast of magnetic resonance imaging (MRI) and no extra ionizing radiation, PET/MRI imaging is the hottest topic currently. PET/MRI is swiftly making its way into clinical practice. However, it has many technical difficulties to overcome, such as photomultiplier tubes, which cannot work properly in a magnetic field, and the inability to provide density information on the object for attenuation correction. This paper introduces the technique process of PET/MRI and summarizes its clinical applications, including imaging in oncology, neurology, and cardiology.
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